Juliet Flanagan - Distinction Presentation

4/13/2019 9:00 AM to 4/13/2019 10:00 AM

CPT - Center for Performance & Technology - Classroom/Computer Lab - T231 - T231

Optimizing Western Blots to Assess Genetic Variation in Strains of the Epstein-Barr Isolated from Burkett Lymphomas

The Epstein-Barr virus (EBV) has been associated with several types of cancers including the most common childhood cancer in tropical Africa: Burkitt Lymphoma (BL). B95-8 - a strain of EBV originally isolated from an infectious mononucleosis patient - can be grown to high concentrations in the lab and thus has been used as a model for strain for most EBV studies to date. However, now "wild-type" viruses can be isolated from tumors and grown up in the lab in comparable amounts to the B95-8 model strain. This new development leads scientist to question the accuracy of B95-8 as an effective model for novel EBV strains. This project uses Western Blots to compare protein expression and gene variation in the B95-8 model and two novel BL strains.

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Louisiana School for Math, Science, and the Arts (LSMSA) is the preeminent state-supported residential high school with competitive admissions for Louisiana's high-achieving, highly-motivated sophomores, juniors, and seniors. As a public school, there is no tuition to attend, and assistance from the LSMSA Foundation ensures the program is available to all qualifying students regardless of family financial need.